SCHEMBL6186320

SCHEMBL6186320

COc1ccc(S(=O)(=O)N2CCc3cccc(Cl)c3C2)cc1N1CCN(C)CC1

nearest known ligand 0.82

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 14/20 0.82
AKR1C3 P42330 1/20 0.54
AKR1C2 P52895 1/20 0.54
AKR1C1 Q04828 1/20 0.54
NPSR1 Q6W5P4 2/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C19 P33261 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.52
USP2 O75604 1/20 0.51
LMNA P02545 1/20 0.51
GLA P06280 1/20 0.51
TSHR P16473 1/20 0.51
MAPK1 P28482 1/20 0.51
HSD17B10 Q99714 1/20 0.51
ALDH1A1 P00352 1/20 0.47
HPGD P15428 1/20 0.47
HTT P42858 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6188691 0.99 HTR6 (0.81) HTR6AKR1C3AKR1C2AKR1C1NPSR1
SCHEMBL6186188 0.90 HTR6 (1.00) HTR6AKR1C3AKR1C2AKR1C1NPSR1
Hydrochloric Acid SCHEMBL6187082 0.90 HTR6 (0.98) HTR6AKR1C3AKR1C2AKR1C1NPSR1
SCHEMBL6186973 0.89 HTR6 (0.80) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6186037 0.88 HTR6 (0.65) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6187107 0.88 HTR6 (0.65) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
Hydrochloric Acid SCHEMBL6187971 0.88 HTR6 (0.78) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
Hydrochloric Acid SCHEMBL6187379 0.87 HTR6 (0.64) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
SCHEMBL27408461 0.86 CYP3A4 (0.73) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2
SCHEMBL6185504 0.85 HTR6 (0.60) HTR6NPSR1CYP3A4CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP claimed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 CN claimed
US-6316450-B1 PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-13 US claimed
EP-0994862-B1 SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION SMITHKLINE BEECHAM PLC (GB) 2005-06-01 EP disclosed
CN-1087294-C Novel compounds SMITHKLINE BEECHAM PLC (GB) 2002-07-10 CN disclosed
US-6316450-B1 PIPERAZINE COMPOUNDS FOR TREATING DEPRESSION AND ANXIETY SMITHKLINE BEECHAM P.L.C. (GB) 2001-11-13 US disclosed