Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.65 |
| ▸ | CDK1 | P06493 | 11/20 | 0.65 |
| ▸ | SRC | P12931 | 9/20 | 0.65 |
| ▸ | ABL1 | P00519 | 15/20 | 0.64 |
| ▸ | PRKCA | P17252 | 11/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.51 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190187 | 0.99 | EGFR (0.66) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189435 | 0.88 | EGFR (0.58) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188074 | 0.87 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189300 | 0.86 | EGFR (0.67) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187292 | 0.85 | EGFR (0.64) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188881 | 0.85 | EGFR (0.69) | EGFRCDK1SRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6184769 | 0.85 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6185929 | 0.85 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6185990 | 0.84 | EGFR (0.67) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187847 | 0.84 | EGFR (0.65) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |