Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.58 |
| ▸ | CDK1 | P06493 | 9/20 | 0.58 |
| ▸ | SRC | P12931 | 8/20 | 0.58 |
| ▸ | ABL1 | P00519 | 13/20 | 0.57 |
| ▸ | PRKCA | P17252 | 9/20 | 0.57 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186746 | 0.88 | EGFR (0.65) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6190187 | 0.87 | EGFR (0.66) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188074 | 0.81 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189300 | 0.81 | EGFR (0.67) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187292 | 0.80 | EGFR (0.64) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188881 | 0.80 | EGFR (0.69) | EGFRCDK1SRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6184769 | 0.79 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6185929 | 0.79 | EGFR (0.71) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187847 | 0.79 | EGFR (0.65) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6186672 | 0.78 | EGFR (0.76) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |