Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833669 | 0.80 | TP53 (0.64) | MAPTTP53POLBALOX5SMN1; SMN2 | |
| SCHEMBL5220859 | 0.77 | PKM (0.47) | MAPTTP53CA12CA1CA2 | |
| SCHEMBL1583553 | 0.73 | TP53 (0.52) | MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL5396171 | 0.72 | MAPT (0.60) | MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL5222204 | 0.71 | TP53 (0.47) | MAPTTP53POLBSMN1; SMN2 | |
| SCHEMBL475737 | 0.70 | POLB (0.55) | MAPTTP53CA1CA2CA7 | |
| SCHEMBL18767065 | 0.69 | POLB (0.54) | MAPTTP53POLBSMN1; SMN2PTGER1 | |
| SCHEMBL5901042 | 0.69 | TP53 (0.48) | MAPTTP53POLBSMN1; SMN2PTGER1 | |
| SCHEMBL5218797 | 0.69 | NPC1 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8275567 | 0.69 | MAPT (0.59) | MAPTTP53POLBSMN1; SMN2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050619-A1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LIMITED (GB) | 2004-06-17 | — | — | WO | disclosed |