Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188627 | 0.99 | MAOB (0.47) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6187153 | 0.97 | MAOB (0.45) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6187433 | 0.95 | MAOB (0.43) | MAOBMAOASTK17BSTK17ASMN1; SMN2 | |
| SCHEMBL6189592 | 0.93 | MAOA (0.51) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6185134 | 0.93 | MAOA (0.54) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6189884 | 0.91 | MAOA (0.48) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6186285 | 0.90 | MAOA (0.49) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6184788 | 0.89 | MAOA (0.45) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6186131 | 0.88 | MAOA (0.47) | MAOBMAOANPSR1STK17BSTK17A | |
| SCHEMBL6189327 | 0.88 | HPGD (0.46) | MAOBMAOANPSR1STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |