Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21333228 | 1.00 | MEN1 (0.55) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL27370508 | 0.83 | ALDH1A1 (0.49) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL11153839 | 0.81 | MEN1 (0.55) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL11153843 | 0.81 | MEN1 (0.55) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL11153841 | 0.81 | MEN1 (0.55) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL27865872 | 0.80 | CNR2 (0.59) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL10585859 | 0.79 | MEN1 (0.57) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL6253478 | 0.79 | MEN1 (0.57) | MEN1KMT2AHDAC8HDAC6EPHX2 | |
| SCHEMBL30866449 | 0.79 | MAPT (0.57) | MEN1KMT2AHDAC8HDAC6HPGD | |
| SCHEMBL2750185 | 0.79 | MEN1 (0.61) | MEN1KMT2AHDAC8HDAC6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |