SCHEMBL6186981

SCHEMBL6186981

CC(CNC(=O)OC(C)(C)C)c1ccc(C(O)c2cc(Cl)ccc2NCc2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.43
CCNE2 O96020 1/20 0.39
CCNA2 P20248 1/20 0.39
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CCNA1 P78396 1/20 0.39
CTSS P25774 2/20 0.38
CTSK P43235 2/20 0.38
GAA P10253 1/20 0.37
LMNA P02545 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
ADAMTS5 Q9UNA0 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6191245 0.93 HDAC1 (0.42) HDAC1CCNE2CCNA2CCNE1CDK2
SCHEMBL6186419 0.89 HDAC1 (0.43) HDAC1CTSSCTSKGAALMNA
SCHEMBL6188677 0.83 HDAC1 (0.44) HDAC1CCNE2CCNA2CCNE1CDK2
SCHEMBL6188632 0.83 BCHE (0.42) HDAC1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL8210584 0.81 MAPT (0.37) GAALMNAMAPT
SCHEMBL6189547 0.81 MRGPRX4 (0.41) HDAC1CTSKGAALMNACYP1A2
SCHEMBL6188282 0.79 GAA (0.45) HDAC1GAACYP1A2CYP3A4CYP2D6
SCHEMBL6188238 0.79 HDAC1 (0.47) HDAC1CTSSCTSKGAAHTT
SCHEMBL6191215 0.78 AAK1 (0.40) GAAMAPTHTTNPSR1CTSL
SCHEMBL6191680 0.77 GAA (0.41) HDAC1GAALMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0979227-B1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA PHARMACEUTICAL (JP) 2005-11-16 EP disclosed
US-6352982-B1 TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-05 US disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed