SCHEMBL6186419

SCHEMBL6186419

CC(C)(C)OC(=O)NCCc1ccc(C(O)c2cc(Cl)ccc2NCc2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.43
CNR1 P21554 1/20 0.40
NAMPT P43490 1/20 0.39
CTSK P43235 2/20 0.39
CTSS P25774 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
GAA P10253 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 2/20 0.38
ADAMTS5 Q9UNA0 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ADRB3 P13945 2/20 0.37
SUCNR1 Q9BXA5 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TP53 P04637 1/20 0.37
GLA P06280 1/20 0.37
HPGD P15428 1/20 0.37
XBP1 P17861 1/20 0.37
HTT P42858 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6186981 0.89 HDAC1 (0.43) HDAC1CTSKCTSSGAALMNA
SCHEMBL6191245 0.84 HDAC1 (0.42) HDAC1CTSKCTSSGAALMNA
SCHEMBL6189547 0.81 MRGPRX4 (0.41) HDAC1CTSKGAALMNAMAPT
SCHEMBL6188282 0.80 GAA (0.45) HDAC1NAMPTGAAHTTNPSR1
SCHEMBL6188262 0.80 CA2 (0.44) NAMPTGAALMNAMAPTKDM4E
SCHEMBL6188238 0.79 HDAC1 (0.47) HDAC1CTSKCTSSGAAADAMTS5
SCHEMBL5208318 0.79 HDAC1 (0.43) HDAC1CNR1TAAR1ADAMTS5KDM4E
SCHEMBL6189480 0.79 KDM4E (0.41) CNR1CTSKCTSSMAPTKDM4E
SCHEMBL6191680 0.77 GAA (0.41) HDAC1NAMPTGAALMNAMAPT
SCHEMBL18800977 0.77 NAMPT (0.58) HDAC1CNR1NAMPTCTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0979227-B1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA PHARMACEUTICAL (JP) 2005-11-16 EP disclosed
US-6352982-B1 TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-05 US disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed