Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | DRD3 | P35462 | 2/20 | 0.70 |
| ▸ | HTR2B | P41595 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.70 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ranolazine SCHEMBL124666 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL30296819 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL124665 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL6391141 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL7933344 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL1495098 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL1534086 | 0.83 | CYP3A4 (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL612077 | 0.82 | LMNA (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL14841986 | 0.82 | CYP3A4 (0.98) | CYP3A4CYP2D6TSHRADRB1ADRA2A | |
| Ranolazine SCHEMBL230758 | 0.82 | LMNA (1.00) | CYP3A4CYP2D6TSHRADRB1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567525-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052887-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |