Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | BACE1 | P56817 | 1/20 | 0.62 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.52 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30523653 | 0.85 | BCHE (0.66) | BCHEACHEBACE1GRM2GRM3 | |
| SCHEMBL22361728 | 0.85 | BCHE (0.66) | BCHEACHEBACE1GRM2GRM3 | |
| SCHEMBL18143026 | 0.83 | GAA (0.49) | BCHEACHEBACE1KDM1AKMT2A | |
| SCHEMBL694951 | 0.82 | BCHE (0.65) | BCHEACHEBACE1GRM2GRM3 | |
| SCHEMBL4205757 | 0.78 | ALDH1A1 (0.59) | BCHEACHEBACE1ALDH1A1EPHX2 | |
| SCHEMBL6186246 | 0.78 | CXCR4 (0.43) | BCHEACHEBACE1KMT2AALDH1A1 | |
| SCHEMBL5992982 | 0.76 | BCHE (0.58) | BCHEACHEBACE1GRM2GRM3 | |
| SCHEMBL951933 | 0.74 | ALDH1A1 (0.57) | BCHEACHEBACE1GRM2GRM3 | |
| SCHEMBL951932 | 0.74 | ALDH1A1 (0.57) | BCHEACHEBACE1GRM2GRM3 | |
| Hydrochloric Acid SCHEMBL4226162 | 0.74 | GRM2 (0.65) | BCHEACHEBACE1GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569905-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052858-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |