Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.59 |
| ▸ | CDK2 | P24941 | 6/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.59 |
| ▸ | CDK1 | P06493 | 2/20 | 0.59 |
| ▸ | CDK4 | P11802 | 2/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.59 |
| ▸ | CCND1 | P24385 | 2/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CCNH | P51946 | 1/20 | 0.59 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836734 | 0.94 | CCNE1 (0.59) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL13934304 | 0.83 | CDK2 (0.67) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL5835710 | 0.82 | CCNE1 (0.61) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL5835640 | 0.81 | CCNE1 (0.59) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL6174422 | 0.80 | CCNE1 (0.55) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL28748028 | 0.78 | PSEN1 (0.49) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL5836908 | 0.78 | CCNE1 (0.55) | CCNE1CDK2CDK5CDK1CDK4 | |
| SCHEMBL22689917 | 0.78 | HDAC8 (0.56) | SIRT2SIRT1FOLH1MMEECE1 | |
| SCHEMBL9696080 | 0.77 | CAPN1 (0.54) | ALDH1A1SIRT2SIRT1FOLH1MME | |
| SCHEMBL10652580 | 0.76 | PPARA (0.51) | ALDH1A1SIRT2SIRT1FOLH1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | claimed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | claimed |