Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.51 |
| ▸ | CDK1 | P06493 | 9/20 | 0.51 |
| ▸ | SRC | P12931 | 9/20 | 0.51 |
| ▸ | ABL1 | P00519 | 14/20 | 0.50 |
| ▸ | PRKCA | P17252 | 8/20 | 0.50 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6189653 | 0.90 | EGFR (0.51) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6186914 | 0.90 | EGFR (0.48) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6187529 | 0.89 | EGFR (0.53) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6188933 | 0.87 | MKNK1 (0.57) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6189380 | 0.86 | EGFR (0.47) | EGFRCDK1SRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6190351 | 0.84 | EGFR (0.56) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL6184740 | 0.83 | EGFR (0.55) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8115748 | 0.75 | EGFR (0.77) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL8122758 | 0.75 | EGFR (0.61) | EGFRCDK1SRCABL1PRKCA | |
| SCHEMBL4935748 | 0.74 | EGFR (0.65) | EGFRCDK1SRCABL1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |