Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.57 |
| ▸ | CDK1 | P06493 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 9/20 | 0.51 |
| ▸ | SRC | P12931 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 6/20 | 0.46 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6186914 | 0.89 | EGFR (0.48) | MKNK1CDK1EGFRSRCABL1 | |
| SCHEMBL6187701 | 0.87 | EGFR (0.51) | CDK1EGFRSRCABL1PRKCA | |
| SCHEMBL6189653 | 0.85 | EGFR (0.51) | CDK1EGFRSRCABL1PRKCA | |
| SCHEMBL6187529 | 0.84 | EGFR (0.53) | CDK1EGFRSRCKITABL1 | |
| SCHEMBL6189380 | 0.81 | EGFR (0.47) | CDK1EGFRSRCABL1PRKCA | |
| Hydrochloric Acid SCHEMBL6190351 | 0.79 | EGFR (0.56) | CDK1EGFRSRCABL1PRKCA | |
| SCHEMBL6184740 | 0.79 | EGFR (0.55) | CDK1EGFRSRCABL1PRKCA | |
| SCHEMBL8124691 | 0.76 | CDK1 (0.76) | MKNK1CDK1EGFRSRCABL1 | |
| SCHEMBL6185571 | 0.74 | EGFR (0.60) | MKNK1CDK1EGFRSRCABL1 | |
| SCHEMBL8128712 | 0.74 | EGFR (0.66) | MKNK1CDK1EGFRSRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929553-B1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| US-6251911-B1 | Pyrimidine derivatives and processes for the preparation thereof | NOVARTIS AG (CH) | 2001-06-26 | — | — | US | disclosed |
| EP-0929553-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998014450-A1 | PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 1998-04-09 | — | — | WO | disclosed |