Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.49 |
| ▸ | GRM8 | O00222 | 1/20 | 0.48 |
| ▸ | GRM6 | O15303 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6191530 | 1.00 | TSHR (0.54) | TSHRALDH1A1LMNAKMOGRM8 | |
| SCHEMBL30537970 | 1.00 | TSHR (0.54) | TSHRALDH1A1LMNAKMOGRM8 | |
| SCHEMBL16836911 | 1.00 | TSHR (0.54) | TSHRALDH1A1LMNAKMOGRM8 | |
| Hydrochloric Acid SCHEMBL6749409 | 0.98 | TSHR (0.53) | TSHRALDH1A1LMNAKMOGRM8 | |
| Hydrochloric Acid SCHEMBL29643165 | 0.98 | TSHR (0.53) | TSHRALDH1A1LMNAKMOGRM8 | |
| Hydrochloric Acid SCHEMBL6751569 | 0.98 | TSHR (0.53) | TSHRALDH1A1LMNAKMOGRM8 | |
| SCHEMBL30762196 | 0.86 | TSHR (0.56) | TSHRALDH1A1LMNAKMOGRM8 | |
| SCHEMBL8385351 | 0.84 | TSHR (0.57) | TSHRALDH1A1LMNAKMOGRM8 | |
| SCHEMBL27460769 | 0.84 | KMO (0.52) | TSHRALDH1A1KMOGRM8GRM6 | |
| SCHEMBL1205506 | 0.82 | TSHR (0.59) | TSHRALDH1A1LMNAGRM8GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299365-B1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2005-09-28 | — | — | EP | disclosed |
| EP-1299365-A1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | Aventis Pharma S.A. (FR) | 2003-04-09 | — | — | EP | disclosed |
| WO-2001094325-A1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2001-12-13 | — | — | WO | disclosed |