Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 2/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.46 |
| ▸ | DAPK2 | Q9UIK4 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187132 | 0.96 | MAOA (0.50) | MAOAMAOBSTK17BSTK17ADAPK3 | |
| SCHEMBL6189454 | 0.96 | MAOA (0.53) | MAOAMAOBSTK17BSTK17AULK1 | |
| SCHEMBL6188606 | 0.95 | MAOA (0.55) | MAOAMAOBSTK17BSTK17AGAA | |
| SCHEMBL6189327 | 0.90 | HPGD (0.46) | MAOAMAOBSTK17BSTK17ADAPK3 | |
| SCHEMBL6184788 | 0.89 | MAOA (0.45) | MAOAMAOBSTK17BSTK17ADAPK3 | |
| SCHEMBL6187035 | 0.89 | PARP1 (0.48) | MAOAMAOBSTK17BSTK17ADAPK3 | |
| SCHEMBL6186285 | 0.86 | MAOA (0.49) | MAOAMAOBSTK17BSTK17AULK1 | |
| SCHEMBL6187433 | 0.85 | MAOB (0.43) | MAOAMAOBSTK17BSTK17ADAPK3 | |
| SCHEMBL6185134 | 0.85 | MAOA (0.54) | MAOAMAOBSTK17BSTK17ALMNA | |
| SCHEMBL6189884 | 0.85 | MAOA (0.48) | MAOAMAOBSTK17BSTK17ADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |