Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 18/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 18/20 | 0.63 |
| ▸ | HRH2 | P25021 | 4/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HRH1 | P35367 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.56 |
| ▸ | HTR1E | P28566 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | HTR5A | P47898 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24229547 | 0.90 | TMEM97 (0.66) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL14477367 | 0.89 | TMEM97 (0.66) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL6190050 | 0.87 | TMEM97 (0.62) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL16173559 | 0.87 | TMEM97 (0.62) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL6187231 | 0.85 | TMEM97 (0.60) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL27538580 | 0.83 | HRH3 (0.52) | HRH3 | |
| SCHEMBL1299903 | 0.82 | TMEM97 (0.70) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL30515329 | 0.82 | TMEM97 (0.70) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL1300458 | 0.81 | TMEM97 (0.60) | TMEM97SIGMAR1HRH2HTR2CHRH1 | |
| SCHEMBL6189797 | 0.80 | NR1H2 (0.63) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070714-A9 | AMIDINE COMPOUNDS | JAPAN TOBACCO INC. (JP) | 2005-10-19 | — | — | EP | disclosed |
| EP-1070714-B1 | AMIDINE COMPOUNDS | JAPAN TOBACCO INC (JP) | 2004-08-04 | — | — | EP | disclosed |
| US-20040006099-A1 | Amidine compounds | JAPAN TOBACCO INC. | 2004-01-08 | — | — | US | disclosed |
| US-6562828-B1 | Novel amidine compound having a blood coagulation factor Xa inhibitory activity | JAPAN TOBACCO INC. (JP) | 2003-05-13 | — | — | US | disclosed |
| CN-1305470-A | Amidine compounds | JAPAN TOBACCO INC (JP) | 2001-07-25 | — | — | CN | disclosed |
| EP-1070714-A1 | AMIDINE COMPOUNDS | JAPAN TOBACCO INC. (JP) | 2001-01-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006099-A1 | Amidine compounds | F2, SERPINC1, F12 | TMEM97 4208/4885SIGMAR1 1553/4885HRH2 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.