Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185867 | 0.87 | CNR2 (0.43) | POLBMAPK1MEN1KMT2ACNR2 | |
| SCHEMBL6186229 | 0.80 | ADRB2 (0.38) | SLC6A4SLC6A3IDO1TDO2POLB | |
| SCHEMBL6186361 | 0.77 | PPARG (0.43) | SLC6A4SLC6A2SLC6A3PPARGPPARA | |
| SCHEMBL6187841 | 0.75 | CYP2D6 (0.43) | SLC6A4SLC6A2SLC6A3IDO1TDO2 | |
| SCHEMBL6186208 | 0.73 | PPARG (0.43) | SLC6A4PPARGPPARALMNAMEN1 | |
| SCHEMBL6192279 | 0.70 | BRD4 (0.45) | SLC6A4SLC6A3PPARGPPARAPOLB | |
| SCHEMBL6187976 | 0.69 | ADRB2 (0.41) | SLC6A4SLC6A3IDO1TDO2POLB | |
| SCHEMBL5289693 | 0.68 | PPARG (0.49) | SLC6A4SLC6A2SLC6A3PPARGPPARA | |
| SCHEMBL10977277 | 0.67 | SLC6A4 (0.52) | SLC6A4SLC6A3IDO1TDO2MAPK1 | |
| SCHEMBL15617669 | 0.67 | SLC6A2 (0.49) | SLC6A4SLC6A2SLC6A3IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539685-A1 | MCP-1 RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF | Warner-Lambert Company LLC (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004014847-A1 | MCP-1 RECEPTOR ANTAGONISTS AND METHOD OF USE THEREOF | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |