SCHEMBL6188836

SCHEMBL6188836

Cc1nc2c(s1)Cc1cc(-c3cccc(Cl)c3)ccc1-2

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 15/20 0.58
TDP2 O95551 1/20 0.46
LMNA P02545 1/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6191569 0.85 ADORA1 (0.50) ADORA1TDP2LMNATP53MAPT
Hydrochloric Acid SCHEMBL7895436 0.84 ADORA1 (0.49) ADORA1TDP2LMNATP53MAPT
Iodide SCHEMBL3994778 0.73 ADORA1 (0.84) ADORA1
SCHEMBL12798139 0.73 CHEK1 (0.65) ADORA1TP53MAPT
SCHEMBL2091654 0.71 KDM1A (0.48) ADORA1
SCHEMBL6190822 0.70 ADORA1 (0.49) ADORA1TDP2MAPT
Iodide SCHEMBL3990143 0.69 ADORA1 (0.78) ADORA1
SCHEMBL2091651 0.69 PTGS1 (0.47) ADORA1
SCHEMBL11964988 0.69 ADORA2A (0.48) ADORA1
Bromide SCHEMBL7903347 0.68 ADORA1 (0.48) ADORA1TDP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1183247-B1 POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS AVENTIS PHARMA GMBH (DE) 2005-05-25 EP disclosed
EP-1156805-B1 USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR MANUFACTURING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY AVENTIS PHARMA GMBH (DE) 2004-08-11 EP disclosed
EP-1183247-A1 POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS Aventis Pharma Deutschland GmbH (DE) 2002-03-06 EP disclosed
US-6329407-B1 ANOREXOGENIC AGENTS AVENTISPHARMA DEUTSCHLAND GMBH (DE) 2001-12-11 US disclosed
EP-1156805-A2 USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY Aventis Pharma Deutschland GmbH (DE) 2001-11-28 EP disclosed
US-6187801-B1 6-CHLORO-2-METHYL-8H-INDENO(1,2-D)-THIAZOLE HYDROCHLORIDE, FOR EXAMPLE; ADMINISTERING TO TREAT OBESITY, DIABETES; ANORECTICS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-02-13 US disclosed
WO-2000051579-A2 USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-09-08 WO disclosed
WO-2000051997-A1 POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-09-08 WO disclosed