Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 12/20 | 0.49 |
| ▸ | FBP1 | P09467 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7903347 | 0.98 | ADORA1 (0.48) | ADORA1FBP1CHEK1DAPK3LTK | |
| SCHEMBL6191799 | 0.89 | ADORA1 (0.42) | ADORA1FBP1NPC1TDP2ALDH1A1 | |
| Iodide SCHEMBL3987555 | 0.81 | ADORA1 (0.73) | ADORA1FBP1CHEK1DAPK3LTK | |
| SCHEMBL6191569 | 0.77 | ADORA1 (0.50) | ADORA1FBP1CHEK1DAPK3LTK | |
| Hydrochloric Acid SCHEMBL7895436 | 0.76 | ADORA1 (0.49) | ADORA1FBP1CHEK1DAPK3LTK | |
| SCHEMBL12798139 | 0.75 | CHEK1 (0.65) | ADORA1FBP1CHEK1DAPK3LTK | |
| SCHEMBL17339841 | 0.72 | CHEK1 (0.47) | ADORA1FBP1CHEK1DAPK3LTK | |
| SCHEMBL13827812 | 0.71 | FBP1 (0.36) | ADORA1FBP1GAANPC1ALDH1A1 | |
| SCHEMBL10356404 | 0.68 | KDM4E (0.33) | ADORA1GAANPC1ALDH1A1MAPT | |
| SCHEMBL10356745 | 0.67 | RAB9A (0.46) | ADORA1GAANPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183247-B1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA GMBH (DE) | 2005-05-25 | — | — | EP | disclosed |
| EP-1156805-B1 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR MANUFACTURING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | AVENTIS PHARMA GMBH (DE) | 2004-08-11 | — | — | EP | disclosed |
| EP-1183247-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| EP-1156805-A2 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | Aventis Pharma Deutschland GmbH (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051997-A1 | POLYCYCLIC THIAZOLE SYSTEMS AND THEIR UTILIZATION AS ANORECTICS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000051579-A2 | USE OF POLYCYCLIC THIAZOLE SYSTEMS FOR PRODUCING MEDICAMENTS FOR PREVENTING OR TREATING OBESITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |