Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.78 |
| ▸ | HTR1A | P08908 | 1/20 | 0.78 |
| ▸ | DRD2 | P14416 | 1/20 | 0.78 |
| ▸ | HTR1D | P28221 | 1/20 | 0.78 |
| ▸ | HTR1B | P28222 | 1/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.78 |
| ▸ | HTR7 | P34969 | 1/20 | 0.78 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.78 |
| ▸ | DRD3 | P35462 | 1/20 | 0.78 |
| ▸ | HTR2B | P41595 | 1/20 | 0.78 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.78 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.63 |
| ▸ | HTR3B | O95264 | 1/20 | 0.63 |
| ▸ | HTR3A | P46098 | 1/20 | 0.63 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.63 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6185776 | 0.88 | HTR6 (1.00) | HTR6HTR1ADRD2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6187310 | 0.87 | HTR6 (0.98) | HTR6HTR1ADRD2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6186496 | 0.85 | HTR6 (0.74) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL6185518 | 0.82 | HTR6 (1.00) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL6186019 | 0.82 | HTR6 (0.72) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL6188240 | 0.82 | HTR6 (1.00) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL6189857 | 0.81 | HTR6 (1.00) | HTR6HTR1ADRD2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6188510 | 0.81 | HTR6 (0.98) | HTR6HTR1ADRD2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6187722 | 0.81 | HTR6 (0.70) | HTR6HTR1ADRD2HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL6190373 | 0.81 | HTR6 (0.98) | HTR6HTR1ADRD2HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994862-B1 | SULPHONAMIDE DERIVATIVES BEING 5-HT6 RECEPTOR ANTAGONISTS AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2005-06-01 | — | — | EP | claimed |