Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.54 |
| ▸ | SGK1 | O00141 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522859 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13LCKKDRCSF1R | |
| SCHEMBL6172096 | 0.83 | MAPK14 (0.55) | MAPK14MAPK13SGK1LCKKDR | |
| SCHEMBL6170492 | 0.83 | MAPK14 (0.55) | MAPK14LCKCSF1R | |
| SCHEMBL6171249 | 0.82 | MAPK14 (0.71) | MAPK14MAPK13SGK1LCKKDR | |
| SCHEMBL3525957 | 0.78 | MAPK14 (0.84) | MAPK14MAPK13SGK1LCKKDR | |
| SCHEMBL2950521 | 0.77 | MAPK14 (0.68) | MAPK14LCKKDRCSF1RKIT | |
| SCHEMBL2949595 | 0.77 | MAPK14 (0.68) | MAPK14LCKKDRCSF1RKIT | |
| SCHEMBL6171833 | 0.77 | MAPK14 (0.65) | MAPK14MAPK13SGK1LCKKDR | |
| SCHEMBL3524620 | 0.76 | MAPK13 (0.83) | MAPK14MAPK13SGK1LCKKDR | |
| SCHEMBL6168068 | 0.75 | MAPK14 (0.59) | MAPK14MAPK13SGK1LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531812-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004010995-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRISTIS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-05 | — | — | WO | disclosed |