Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824786 | 1.00 | SIGMAR1 (0.54) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| Hydrochloric Acid SCHEMBL5967359 | 0.98 | SIGMAR1 (0.53) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| SCHEMBL10608616 | 0.90 | CYP2D6 (0.58) | SIGMAR1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10611156 | 0.90 | CYP2D6 (0.58) | SIGMAR1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10766683 | 0.90 | CYP2D6 (0.58) | SIGMAR1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL2398120 | 0.86 | KMT2A (0.66) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| SCHEMBL2398115 | 0.86 | KMT2A (0.66) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| SCHEMBL7733774 | 0.85 | MAPT (0.55) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| SCHEMBL7733778 | 0.85 | MAPT (0.55) | SIGMAR1KMT2ATSHRMEN1OPRK1 | |
| SCHEMBL9267311 | 0.84 | SIGMAR1 (0.56) | SIGMAR1KMT2ATSHRMEN1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554250-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004031154-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |