SCHEMBL6192178

SCHEMBL6192178

CC(C)(C)OC(=O)NCc1cccc(C(=O)c2ccccc2)c1N

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 1/20 0.48
ABCB11 O95342 1/20 0.44
LMNA P02545 1/20 0.44
PTGS1 P23219 1/20 0.44
ADORA1 P30542 1/20 0.44
PTGS2 P35354 1/20 0.44
KDM4A O75164 1/20 0.42
PPARG P37231 3/20 0.40
PPARA Q07869 3/20 0.40
PPARD Q03181 2/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8206463 0.84 KCNA5 (0.43) KCNA5KDM4AHDAC1HDAC10HDAC6
SCHEMBL6188718 0.83 EPHX2 (0.41) KCNA5LMNAKDM4AHDAC1GAA
SCHEMBL8198762 0.82 KDM4A (0.40) KCNA5PTGS1PTGS2KDM4APPARG
SCHEMBL6189596 0.80 POLB (0.41) KCNA5LMNAKDM4APPARGPPARA
SCHEMBL1808874 0.79 KCNA5 (0.56) KCNA5KDM4AHDAC1HDAC10HDAC6
SCHEMBL8018113 0.78 KCNA5 (0.56) KCNA5LMNAKDM4AHDAC1HDAC10
SCHEMBL30159605 0.78 KCNA5 (0.56) KCNA5LMNAKDM4AHDAC1HDAC10
SCHEMBL29075894 0.78 RIPK1 (0.45) KCNA5KDM4AHDAC1HDAC10HDAC6
SCHEMBL29075992 0.78 POLB (0.47) KCNA5LMNAKDM4AHDAC10HDAC6
SCHEMBL26659635 0.78 KCNA5 (0.55) KCNA5KDM4AHDAC1HDAC10HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0979227-B1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA PHARMACEUTICAL (JP) 2005-11-16 EP disclosed
US-6352982-B1 TREATING DIABETES, OBESITY, OR INVETERATE DIARRHEA IN A MAMMAL WHICH COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF A COMPOUND OF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-03-05 US disclosed
CN-1252795-A 4, 1-benzoxazepine *, their analogs and their use as somatostatin agonists TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2000-05-10 CN disclosed
EP-0979227-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS Takeda Chemical Industries, Ltd. (JP) 2000-02-16 EP disclosed
WO-1998047882-A1 4,1-BENZOXAZEPINES, THEIR ANALOGUES, AND THEIR USE AS SOMATOSTATIN AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-10-29 WO disclosed