SCHEMBL6195033

SCHEMBL6195033

COC(=O)c1ccc2c(n1)SC(=O)CN2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 4/20 0.36
PARP1 P09874 3/20 0.35
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CRBN Q96SW2 1/20 0.33
MAPT P10636 3/20 0.33
CYP1A2 P05177 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
PTGER4 P35408 1/20 0.33
PIM1 P11309 1/20 0.33
GAA P10253 1/20 0.33
RECQL P46063 1/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
OGA O60502 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6644891 0.75 ALDH1A1 (0.35) KMT2AL3MBTL1MAPTSMN1; SMN2HPGD
SCHEMBL6636370 0.75 NPSR1 (0.34) KMT2AL3MBTL1MAPTPIM1GAA
SCHEMBL23530100 0.68 MKNK2 (0.39) MAPK1PARP1L3MBTL1CRBNMAPT
SCHEMBL30791992 0.68 MKNK2 (0.39) MAPK1PARP1L3MBTL1CRBNMAPT
SCHEMBL287974 0.68 MAPK1 (0.39) MAPK1PARP1L3MBTL1CRBNMAPT
SCHEMBL23529904 0.67 MAPK1 (0.38) MAPK1PARP1CRBNMAPTCYP1A2
SCHEMBL24251669 0.66 MAPK1 (0.37) MAPK1PARP1MEN1KMT2AL3MBTL1
SCHEMBL20571711 0.66 GAA (0.39) MAPK1PARP1CRBNMAPTCYP1A2
SCHEMBL28621555 0.65 GRM5 (0.43) MAPK1PARP1KMT2AMAPTCYP1A2
SCHEMBL22049686 0.64 MAPK1 (0.36) MAPK1PARP1MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2723737-A1 BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS Kyorin Pharmaceutical Co., Ltd. (JP) 2014-04-30 EP disclosed
WO-2013003383-A1 BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS KYORIN PHARMACEUTICAL CO., LTD. (JP) 2013-01-03 WO disclosed
EP-1537123-A1 COMPOUNDS GLAXO GROUP LIMITED (GB) 2005-06-08 EP disclosed
EP-1470125-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2004-10-27 EP disclosed
WO-2004002992-A1 COMPOUNDS GLAXO GROUP LIMITED (GB) 2004-01-08 WO disclosed
EP-1359908-A1 QUINOLINES AND NITROGENATED DERIVATIVES THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM PLC (GB) 2003-11-12 EP disclosed
WO-2003064421-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-08-07 WO disclosed
WO-2002056882-A1 QUINOLINES AND NITROGENATED DERIVAIVE THEREOF SUBSTITUTED IN 4-POSITION BY A PIPERIDINE-CONTAINING MOIETY AND THEIR USE AS ANTIBACTERIAL AGENTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-07-25 WO disclosed