Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK11A | Q9UQ88 | 9/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.54 |
| ▸ | CDK4 | P11802 | 8/20 | 0.54 |
| ▸ | CCND1 | P24385 | 8/20 | 0.54 |
| ▸ | CDK9 | P50750 | 8/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.44 |
| ▸ | CDK2 | P24941 | 9/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6192104 | 0.88 | CCNT1 (0.58) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6208473 | 0.87 | CCNT1 (0.57) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6193441 | 0.84 | CCNT1 (0.55) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6701026 | 0.81 | CCNA2 (0.54) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6192807 | 0.81 | CCNB2 (0.55) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6195665 | 0.80 | CCNA2 (0.53) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6194186 | 0.80 | CCNT1 (0.57) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6211465 | 0.80 | CCNA2 (0.56) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6194606 | 0.80 | CCNT1 (0.53) | CDK11ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL6194975 | 0.79 | CCNT1 (0.52) | CDK11ACCNT1CDK4CCND1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594866-A1 | ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES | PFIZER INC. (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | PFIZER, INC. | 2004-09-09 | — | — | US | disclosed |
| WO-2004072070-A1 | ANTIPROLIFERATIVE 2-(SULFO-PHENYL)-AMINOTHIAZOLE DERIVATIVES | PFIZER INC. (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176431-A1 | Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives and pharmaceutical compositions, and methods for their use | MKI67, TK1, CDK2 | CDK11A 275/4885CCNT1 7/4885CDK4 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.