Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886413 | 0.80 | KCNA5 (0.48) | KCNA5EDNRAMAOAHIF1AALDH1A1 | |
| SCHEMBL10583963 | 0.80 | KCNA5 (0.48) | KCNA5EDNRAMAOAHIF1AALDH1A1 | |
| SCHEMBL5506979 | 0.79 | KCNA5 (0.47) | KCNA5EDNRAMAOAHIF1AALDH1A1 | |
| SCHEMBL1781983 | 0.79 | KDR (0.50) | KCNA5EDNRAMAOAAURKAROCK2 | |
| SCHEMBL21232730 | 0.77 | HIF1A (0.49) | KCNA5EDNRAMAOAHIF1AAURKA | |
| SCHEMBL19718852 | 0.76 | KCNA5 (0.45) | KCNA5EDNRAMAOAHIF1AALDH1A1 | |
| SCHEMBL1782414 | 0.76 | KCNA5 (0.58) | KCNA5MAOANQO1SGMS1SGMS2 | |
| SCHEMBL6922784 | 0.74 | SGMS2 (0.57) | KCNA5HIF1ALCKALDH1A1HPGD | |
| SCHEMBL19706541 | 0.73 | KCNA5 (0.52) | KCNA5EDNRAHIF1AAURKAROCK2 | |
| SCHEMBL14012657 | 0.72 | KCNA5 (0.61) | KCNA5MAOAHIF1AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572698-A1 | 3-SUBSTITUTED 3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-4-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004055024-A1 | 3-SUBSTITUTED 3,4-DIHYDRO-THIENO[2,3-D]PYRIMIDINE-4-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2004-07-01 | — | — | WO | disclosed |