Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199082 | 0.95 | UTS2R (0.57) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6197465 | 0.92 | UTS2R (0.55) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6197419 | 0.92 | UTS2R (0.55) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6198913 | 0.91 | UTS2R (0.53) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6196317 | 0.90 | UTS2R (0.54) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6197474 | 0.89 | HTR2A (0.53) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6196245 | 0.89 | CXCR3 (0.55) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6196121 | 0.89 | UTS2R (0.56) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6198104 | 0.88 | UTS2R (0.53) | UTS2RADRA2ADRD2SLC6A2HTR2A | |
| SCHEMBL6201161 | 0.87 | UTS2R (0.55) | UTS2RADRA2ADRD2SLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |