Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 7/20 | 0.53 |
| ▸ | TUBB | P07437 | 7/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608533 | 0.80 | CYP1A1 (0.79) | CYP1A1CYP1A2CYP1B1HPGDGAA | |
| SCHEMBL8910406 | 0.80 | CYP1A1 (0.59) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4608535 | 0.80 | CYP1A1 (0.79) | CYP1A1CYP1A2CYP1B1HPGDGAA | |
| SCHEMBL1706535 | 0.78 | CYP1A1 (0.57) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL14198035 | 0.77 | GAA (0.56) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL25345289 | 0.76 | CYP1A1 (0.55) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2622571 | 0.76 | CYP1A1 (0.67) | CYP1A1CYP1A2CYP1B1HPGDGAA | |
| SCHEMBL6199091 | 0.76 | CYP1A1 (0.55) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5804282 | 0.76 | CYP1A1 (0.55) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL96635 | 0.76 | ALDH1A1 (0.59) | CYP3A4MAPTCYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1130017-B1 | Azole derivatives and their use as superoxide radical inhibitors | OTSUKA PHARMA CO LTD (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0934937-B1 | Azole derivatives as superoxide radical inhibitor | OTSUKA PHARMA CO LTD (JP) | 2002-02-27 | — | — | EP | disclosed |
| EP-1130017-A2 | Azole derivatives and their use as superoxide radical inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | disclosed |
| US-6080764-A | PROTECTING VARIOUS TISSUE CELLS FROM DISTURBANCES ASSOCIATED WITH ISCHEMIA AND BLOOD REPERFUSION IN HEART, BRAIN, KIDNEY, LUNG AND DIGESTIVE TRACT BY INHIBITING SUPEROXIDE-RELEASE BY NEUTROPHILIC LEUKOCYTES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0934937-A1 | Azole derivatives as superoxide radical inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5677319-A | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| US-5643932-A | PREVENTS CELL DAMAGE AFTER ISCHEMIA AND RE-PERFUSION, SUBSTITUTED THIAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0513387-A1 | ACTIVE OXYGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-19 | — | — | EP | disclosed |