Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286756 | 0.79 | MAPK1 (0.66) | MAPK1MTNR1AMTNR1BHPGDHSD17B10 | |
| SCHEMBL6197122 | 0.78 | HTR2A (0.55) | MAPK1MTNR1AMTNR1BOPRM1OPRK1 | |
| SCHEMBL7939024 | 0.76 | HTR2A (0.41) | HTR2AHTR2C | |
| SCHEMBL8874163 | 0.74 | MTNR1A (0.72) | MAPK1MTNR1AMTNR1BHTR2C | |
| SCHEMBL7278191 | 0.71 | MAPK1 (0.58) | MAPK1MTNR1AMTNR1BHPGDHSD17B10 | |
| SCHEMBL6196615 | 0.64 | MAPK1 (0.43) | MAPK1MTNR1AMTNR1BHPGDALOX15 | |
| SCHEMBL6717297 | 0.64 | MAPK1 (0.68) | MAPK1MTNR1AMTNR1BHSD17B10KDM4E | |
| SCHEMBL27979414 | 0.64 | MAPK1 (0.67) | MAPK1MTNR1AMTNR1BHSD17B10KDM4E | |
| SCHEMBL20808939 | 0.63 | MAPK1 (0.51) | MAPK1MTNR1AMTNR1BKDM4ETP53 | |
| SCHEMBL5777824 | 0.63 | MAPK1 (0.66) | MAPK1MTNR1AMTNR1BHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |