SCHEMBL6197819

SCHEMBL6197819

COC(=O)c1ccc(-c2ccc(NCc3ccccc3)cn2)s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 13/20 0.60
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
CYP3A4 P08684 1/20 0.54
FAAH O00519 1/20 0.48
GABRP O00591 1/20 0.46
GABRD O14764 1/20 0.46
GABRA1 P14867 1/20 0.46
GABRB1 P18505 1/20 0.46
GABRG2 P18507 1/20 0.46
GABRB3 P28472 1/20 0.46
GABRA5 P31644 1/20 0.46
GABRA3 P34903 1/20 0.46
GABRA2 P47869 1/20 0.46
GABRB2 P47870 1/20 0.46
GABRA4 P48169 1/20 0.46
GABRE P78334 1/20 0.46
GABRA6 Q16445 1/20 0.46
GABRG1 Q8N1C3 1/20 0.46
GABRG3 Q99928 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5903923 0.89 HDAC1 (0.76) HDAC1CYP3A4FAAHHPGDS
SCHEMBL27615071 0.87 HDAC1 (0.67) HDAC1CYP3A4FAAH
SCHEMBL6513231 0.85 HDAC1 (0.59) HDAC1CA1CA2CYP3A4FAAH
SCHEMBL5903726 0.84 MEN1 (0.59) HDAC1HDAC3HDAC4HDAC8HDAC6
SCHEMBL28942341 0.83 HDAC1 (0.49) HDAC1CYP3A4FAAHHDAC3HDAC4
SCHEMBL5903813 0.82 HDAC1 (0.55) HDAC1FAAH
SCHEMBL5903753 0.82 HDAC1 (0.45) HDAC1CYP3A4FAAHHDAC3HDAC4
SCHEMBL5904022 0.81 NPC1 (0.51) HDAC1
SCHEMBL5904070 0.80 HDAC1 (0.61) HDAC1HDAC3HDAC4HDAC7HDAC2
SCHEMBL5904018 0.80 HDAC1 (0.44) HDAC1CYP3A4FAAHHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1525199-A1 SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS Argenta Discovery Limited (GB) 2005-04-27 EP disclosed
WO-2004013130-A1 SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS ARGENTA DISCOVERY LIMITED (GB) 2004-02-12 WO disclosed