Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 7/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6196995 | 0.90 | PDE2A (0.50) | PDE2AMAPK1GHSRMAPTTSHR | |
| SCHEMBL20202573 | 0.85 | MAPK1 (0.51) | PDE2AMAPK1MAPTTSHRKDM4E | |
| SCHEMBL22423076 | 0.85 | PDE2A (0.53) | PDE2AMAPK1GHSRMAPTTSHR | |
| SCHEMBL20207772 | 0.80 | PDE2A (0.52) | PDE2AMAPK1GHSRMAPTKDM4E | |
| SCHEMBL20138445 | 0.77 | PDE2A (0.54) | PDE2AGHSRRIPK2MAPTTSHR | |
| SCHEMBL31194618 | 0.76 | MAPK1 (0.57) | MAPK1TSHRKDM4ECYP1A2SMN1; SMN2 | |
| SCHEMBL18283117 | 0.75 | PDE2A (0.69) | PDE2AMAPK1GHSRMAPTXIAP | |
| SCHEMBL31194511 | 0.75 | RIPK2 (0.43) | MAPK1RIPK2LCKKDRTGFBR1 | |
| SCHEMBL20581431 | 0.74 | PDE2A (0.74) | PDE2AGHSRXIAPKDM4E | |
| SCHEMBL20202564 | 0.74 | PDE2A (0.55) | PDE2AMAPK1GHSRMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |