Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 7/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197831 | 0.90 | PDE2A (0.52) | PDE2AMAPK1GHSRMEN1KMT2A | |
| SCHEMBL22423076 | 0.85 | PDE2A (0.53) | PDE2AMAPK1GHSRMEN1KMT2A | |
| SCHEMBL20202573 | 0.83 | MAPK1 (0.51) | PDE2AMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL20207772 | 0.78 | PDE2A (0.52) | PDE2AMAPK1GHSRALDH1A1KDM4E | |
| SCHEMBL6201447 | 0.77 | TSHR (0.48) | MAPK1GHSRALDH1A1TSHRKDM4E | |
| SCHEMBL20138445 | 0.75 | PDE2A (0.54) | PDE2AGHSRTSHRSRCGAA | |
| SCHEMBL31194618 | 0.75 | MAPK1 (0.57) | MAPK1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL18283117 | 0.73 | PDE2A (0.69) | PDE2AMAPK1GHSRALDH1A1XIAP | |
| SCHEMBL20581431 | 0.73 | PDE2A (0.74) | PDE2AGHSRALDH1A1XIAPKDM4E | |
| SCHEMBL20202564 | 0.72 | PDE2A (0.55) | PDE2AMAPK1GHSRBTKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0995751-B1 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |