Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.66 |
| ▸ | HTR2C | P28335 | 13/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198546 | 0.84 | HTR2A (0.73) | HTR2AHTR2CKDRTRPV1CA1 | |
| SCHEMBL6196811 | 0.82 | HTR2A (0.64) | HTR2AHTR2CNTRK1 | |
| SCHEMBL6201549 | 0.81 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL6198081 | 0.81 | HTR2A (0.80) | HTR2AHTR2C | |
| SCHEMBL6194881 | 0.80 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL6199415 | 0.80 | HTR2A (0.64) | HTR2AHTR2CKDR | |
| SCHEMBL6198959 | 0.80 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL6201624 | 0.80 | HTR2A (1.00) | HTR2AHTR2C | |
| SCHEMBL6196466 | 0.80 | HTR2A (0.69) | HTR2AHTR2C | |
| SCHEMBL6199397 | 0.79 | HTR2A (0.71) | HTR2AHTR2CKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |