Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.71 |
| ▸ | HTR2C | P28335 | 13/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 2/20 | 0.49 |
| ▸ | FLT4 | P35916 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200025 | 0.92 | HTR2A (0.69) | HTR2AHTR2C | |
| SCHEMBL6201549 | 0.92 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL6198546 | 0.89 | HTR2A (0.73) | HTR2AHTR2CBRAFKDR | |
| SCHEMBL6196617 | 0.89 | HTR2A (0.60) | HTR2AHTR2CBRAFKDRCSF1R | |
| SCHEMBL6199703 | 0.89 | HTR2A (0.78) | HTR2AHTR2C | |
| SCHEMBL6198081 | 0.86 | HTR2A (0.80) | HTR2AHTR2C | |
| SCHEMBL6196811 | 0.85 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL6201624 | 0.83 | HTR2A (1.00) | HTR2AHTR2C | |
| SCHEMBL6200743 | 0.83 | HTR2A (0.72) | HTR2AHTR2C | |
| SCHEMBL6197718 | 0.83 | HTR2A (0.69) | HTR2AHTR2CKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |