Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 9/20 | 0.71 |
| ▸ | DRD2 | P14416 | 5/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.71 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859837 | 0.94 | UTS2R (0.77) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4860568 | 0.93 | UTS2R (0.73) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6198939 | 0.91 | UTS2R (0.71) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6197965 | 0.85 | UTS2R (0.52) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4856822 | 0.84 | UTS2R (0.73) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| Hydrochloric Acid SCHEMBL4860288 | 0.83 | UTS2R (0.71) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| Palosuran SCHEMBL1363480 | 0.83 | UTS2R (1.00) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| Palosuran SCHEMBL29441424 | 0.83 | UTS2R (1.00) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4862084 | 0.82 | UTS2R (0.61) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4861140 | 0.82 | UTS2R (0.72) | UTS2RDRD2ADRA2ASLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100424082-C | 4- (piperidinyl-pyrrolidinyl-alkyl-ureido) -quinolines as urotensin II receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-08 | — | — | CN | disclosed |
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |
| CN-1617869-A | 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists | ACTELION PHARMACEUTICALS LTD (CH) | 2005-05-18 | — | — | CN | disclosed |