Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 15/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198208 | 0.91 | CCR3 (0.52) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6199149 | 0.85 | UTS2R (0.71) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6198206 | 0.81 | UTS2R (0.75) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL5527306 | 0.81 | HRH3 (0.68) | UTS2RHDAC8HRH3 | |
| SCHEMBL5735341 | 0.77 | KMT2A (0.63) | DRD2HDAC8DRD3KCNH2HRH3 | |
| SCHEMBL5735461 | 0.77 | MAPT (0.57) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4859837 | 0.77 | UTS2R (0.77) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL4860568 | 0.77 | UTS2R (0.73) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6196552 | 0.76 | UTS2R (0.68) | UTS2RDRD2ADRA2ASLC6A2HTR2A | |
| SCHEMBL6196354 | 0.76 | DRD2 (0.53) | UTS2RDRD2ADRA2ASLC6A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499607-B1 | 4-(PIPERIDYL- AND PYRROLIDYL-ALKYL-UREIDO)-QUINOLINES AS UROTENSIN II RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2005-12-07 | — | — | EP | disclosed |