Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199759 | 0.85 | HTR2A (0.57) | HTR2AHTR2CRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6201228 | 0.84 | HTR2A (0.56) | HTR2AHTR2C | |
| SCHEMBL6198383 | 0.84 | HTR2A (0.61) | HTR2AHTR2CMAPT | |
| SCHEMBL6199862 | 0.82 | HTR2A (0.53) | HTR2AHTR2CEGFR | |
| SCHEMBL2953422 | 0.82 | L3MBTL1 (0.49) | HTR2AMEN1KMT2ARAB9AMAPT | |
| SCHEMBL5947079 | 0.80 | HTR2A (0.53) | HTR2AKMT2ASMN1; SMN2LMNAPOLB | |
| SCHEMBL5946836 | 0.80 | HTR2A (0.50) | HTR2APKMMEN1KMT2ARAB9A | |
| SCHEMBL6196071 | 0.79 | HTR2A (0.62) | HTR2AHTR2C | |
| SCHEMBL5946733 | 0.75 | HTR2A (0.59) | HTR2AMEN1KMT2AHTR2CRAB9A | |
| SCHEMBL5946818 | 0.75 | HTR2A (0.58) | HTR2AMEN1KMT2AHTR2CRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |