Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.43 |
| ▸ | HTR2C | P28335 | 14/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6198210 | 0.91 | HTR2A (0.44) | HTR2AHTR2CHTTSMN1; SMN2 | |
| SCHEMBL6199380 | 0.87 | HTR2A (0.47) | HTR2AHTR2C | |
| SCHEMBL6199131 | 0.86 | HTR2A (0.48) | HTR2AHTR2CHTTSMN1; SMN2 | |
| SCHEMBL6202416 | 0.83 | HTR2A (0.46) | HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL2958211 | 0.82 | L3MBTL1 (0.44) | BRAFHTTCLK1SMN1; SMN2 | |
| SCHEMBL6199782 | 0.80 | HTR2A (0.46) | HTR2AHTR2C | |
| SCHEMBL6586587 | 0.76 | BRAF (0.35) | BRAFCLK1SMN1; SMN2 | |
| SCHEMBL6198696 | 0.74 | HTR2A (0.49) | HTR2AHTR2C | |
| SCHEMBL6196068 | 0.74 | HTR2A (0.46) | HTR2AHTR2CHTT | |
| SCHEMBL6197034 | 0.73 | HTR2A (0.52) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |