Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.70 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668378 | 0.87 | RAF1 (0.76) | RAF1KDRFLT3MAPK13MAPK14 | |
| SCHEMBL668766 | 0.85 | RAF1 (0.69) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL22374639 | 0.83 | RAF1 (1.00) | RAF1MAPK3KDRFLT3MAPK13 | |
| SCHEMBL6200796 | 0.78 | RAF1 (0.59) | RAF1MAPK3KDRFLT3RIPK2 | |
| SCHEMBL686276 | 0.77 | RAF1 (0.66) | RAF1KDRFLT3MAPK13MAPK14 | |
| SCHEMBL668545 | 0.75 | RAF1 (0.59) | RAF1KDRMAPK13MAPK14MAPK12 | |
| SCHEMBL668800 | 0.74 | RAF1 (1.00) | RAF1KDRFLT3MAPK13MAPK14 | |
| SCHEMBL13234850 | 0.73 | RAF1 (1.00) | RAF1MAPK3KDRFLT3MAPK13 | |
| SCHEMBL17229980 | 0.72 | FLT3 (1.00) | RAF1MAPK3KDRFLT3 | |
| SCHEMBL22505710 | 0.72 | KDR (0.58) | RAF1MAPK3KDRFLT3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047418-B1 | INHIBITION OF RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2005-07-27 | — | — | EP | claimed |
| CN-1544420-A | Inhibition of raf kinase using substituted heterocyclic ureas | — | 2004-11-10 | — | — | CN | disclosed |