Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201979 | 0.93 | MCL1 (0.52) | LMNATP53ALDH1A1MCL1KDM4E | |
| SCHEMBL6202196 | 0.92 | SMN1; SMN2 (0.42) | MAPTLMNATP53ALDH1A1MCL1 | |
| SCHEMBL6200211 | 0.89 | MCL1 (0.48) | LMNAALDH1A1MCL1CA2KDM4E | |
| SCHEMBL6197449 | 0.89 | MCL1 (0.48) | LMNAALDH1A1MCL1KDM4EEGLN1 | |
| SCHEMBL6198581 | 0.89 | MCL1 (0.48) | MAPTLMNATP53ALDH1A1MCL1 | |
| SCHEMBL6199917 | 0.88 | MCL1 (0.46) | MAPTLMNAALDH1A1MCL1KDM4E | |
| SCHEMBL6199967 | 0.87 | CCR1 (0.46) | LMNAMCL1EGLN1CNR2PTGER4 | |
| SCHEMBL6201548 | 0.87 | P2RX1 (0.48) | MAPTLMNAMCL1EGLN1CNR2 | |
| SCHEMBL6197457 | 0.87 | KDM4E (0.49) | MAPTLMNATP53ALDH1A1CA2 | |
| SCHEMBL6200195 | 0.86 | MCL1 (0.43) | LMNAMCL1SMN1; SMN2EGLN1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042295-B1 | 4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN CO LLC (US) | 2005-09-07 | — | — | EP | claimed |