⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18954 | 1.00 | — | — | |
| SCHEMBL17667416 | 0.96 | — | — | |
| Methylene Chloride SCHEMBL29088480 | 0.87 | ALDH1A1 (0.30) | — | |
| SCHEMBL29307219 | 0.80 | — | — | |
| SCHEMBL3695772 | 0.78 | — | — | |
| SCHEMBL6305976 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL23577693 | 0.75 | — | — | |
| SCHEMBL18254494 | 0.75 | — | — | |
| SCHEMBL18254496 | 0.75 | — | — | |
| SCHEMBL19573882 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447205-A | Process for preparing -trifluoroisopropanol | GUANGDONG HEC PHARMACEUTICAL | 2015-03-25 | — | — | CN | claimed |
| JP-4745446-B2 | — | — | 2011-08-10 | — | — | JP | claimed |
| EP-2131843-A2 | PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-12-16 | — | — | EP | claimed |
| WO-2008107334-A2 | PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | claimed |
| US-20080221327-A1 | SYNTHESIS OF GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-11 | — | — | US | claimed |
| EP-4577540-A1 | A SCALABLE PROCESS FOR THE PREPARATION OF A GLYT-1 INHIBITOR | Boehringer Ingelheim International GmbH (DE) | 2025-07-02 | — | — | EP | disclosed |
| US-20240083889-A1 | Scalable process for the preparation of a GlyT-1 Inhibitor | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2024-03-14 | — | — | US | disclosed |
| WO-2024042043-A1 | A SCALABLE PROCESS FOR THE PREPARATION OF A GLYT-1 INHIBITOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-02-29 | — | — | WO | disclosed |
| CN-105712945-B | 2-substituted oxy-5-methylsulfonyl aryl piperazine amide analogue and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-106699699-B | The paclitaxel derivatives replaced containing trifluoro isopropyl and its application | 北京康辰药业股份有限公司 | 2019-01-15 | — | — | CN | disclosed |
| CN-106699699-A | Trifluoro isopropyl-substituted taxol derivatives, and applications thereof | 北京康辰药业股份有限公司 | 2017-05-24 | — | — | CN | disclosed |
| CN-105712928-A | 2-Substituted-oxy-5-methylsulfonyl pyridine piperazine acidamide analogue and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2016-06-29 | — | — | CN | disclosed |
| EP-2225202-B1 | Preparation of dihydropyrrol derivatives as intermediates | HOFFMANN LA ROCHE (CH) | 2011-12-28 | — | — | EP | disclosed |
| EP-2131843-B1 | PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |
| US-20100267722-A1 | NOVEL PROLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-21 | — | — | US | disclosed |
| US-7812161-B2 | Reacting 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid with 1-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazine producing [4-(3-fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone | HOFFMAN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-2131843-A2 | PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| US-20090143589-A1 | Preparation of dihydropyrrol derivatives as intermediates | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
| WO-2008107334-A2 | PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |
| US-20080221327-A1 | SYNTHESIS OF GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-11 | — | — | US | disclosed |