Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 7/20 | 0.41 |
| ▸ | TDO2 | P48775 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18236072 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2C19IDO1TDO2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7234524 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19IDO1TDO2ALDH1A1 | |
| SCHEMBL939842 | 0.83 | CYP2C19 (0.50) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL8680427 | 0.83 | CYP2C19 (0.50) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| Methane SCHEMBL28626702 | 0.82 | CYP2C19 (0.48) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL28422465 | 0.80 | CYP2C19 (0.47) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL369647 | 0.80 | CYP2C19 (0.47) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL27547164 | 0.80 | CYP2C19 (0.52) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL7760225 | 0.78 | CYP2C19 (0.46) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL27816063 | 0.78 | SLC6A4 (0.50) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| CN-1390834-A | Indenoindolone compounds, their preparation and medicinal compositions containing them | SEUVILE LAB (FR) | 2003-01-15 | — | — | CN | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |