Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19715854 | 0.81 | ENPP2 (0.40) | GSK3BGLATNFKCNA5ENPP2 | |
| SCHEMBL19729074 | 0.80 | GLA (0.41) | GSK3BGLAKCNA5ENPP2ADRA1D | |
| SCHEMBL21509471 | 0.79 | S1PR1 (0.40) | GSK3BGLAENPP2ADRA1DADRA1A | |
| SCHEMBL6201141 | 0.79 | ENPP2 (0.42) | GSK3BGLATNFKCNA5ENPP2 | |
| SCHEMBL6205271 | 0.77 | CYP2A6 (0.43) | GSK3B | |
| SCHEMBL2650976 | 0.77 | FFAR1 (0.47) | GSK3BGLAFFAR1 | |
| SCHEMBL5099707 | 0.77 | GRM4 (0.45) | GSK3BTNFKCNA5ADRA1DADRA1A | |
| SCHEMBL7116483 | 0.76 | GSK3B (0.49) | GSK3BTNFKCNA5ADRA1DADRA1A | |
| SCHEMBL30583585 | 0.76 | GSK3B (0.47) | GSK3BGLAENPP2ADRA1DADRA1A | |
| SCHEMBL7353222 | 0.76 | GSK3B (0.47) | GSK3BGLATNFENPP2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |