Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30978460 | 0.93 | MAPK1 (0.65) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL109364 | 0.93 | MAPK1 (0.65) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL30271936 | 0.77 | MAPK1 (0.52) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL2134366 | 0.77 | MAPK1 (0.52) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL15932170 | 0.76 | KDM4E (0.56) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL29568623 | 0.75 | MAPK1 (0.65) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL28049209 | 0.75 | KDM4E (0.60) | MAPK1KDM4EALDH1A1L3MBTL1NPC1 | |
| SCHEMBL28020808 | 0.75 | KDM4E (0.60) | MAPK1KDM4EALDH1A1L3MBTL1NPC1 | |
| SCHEMBL424411 | 0.75 | MAPK1 (0.65) | MAPK1KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL31407736 | 0.75 | KDM4E (0.55) | MAPK1KDM4EALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603885-A1 | FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080973-A1 | FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-23 | — | — | WO | disclosed |