Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050309 | 0.81 | CHRM2 (0.54) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL18974099 | 0.81 | CHRM2 (0.54) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL20668990 | 0.81 | CHRM2 (0.56) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL18618112 | 0.78 | CHRM2 (0.54) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL724985 | 0.78 | MEN1 (0.45) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL2737273 | 0.78 | RAB9A (0.55) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL11804742 | 0.75 | RAB9A (0.52) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL16088990 | 0.75 | RAB9A (0.52) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL11783617 | 0.74 | CHRM2 (0.60) | CHRM2CHRM1DRD1SLC6A2ADRA1A | |
| SCHEMBL11804701 | 0.74 | CHRM2 (0.56) | CHRM2CHRM1DRD1SLC6A2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |