Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.48 |
| ▸ | HTR2C | P28335 | 10/20 | 0.39 |
| ▸ | AKT1 | P31749 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199754 | 0.89 | HTR2A (0.48) | HTR2AHTR2C | |
| SCHEMBL6198379 | 0.88 | HTR2A (0.53) | HTR2AHTR2CAKT1 | |
| SCHEMBL6199858 | 0.85 | HTR2A (0.46) | HTR2AHTR2C | |
| SCHEMBL6196066 | 0.85 | HTR2A (0.54) | HTR2AHTR2CHTT | |
| SCHEMBL6196599 | 0.84 | HTR2A (0.48) | HTR2AHTR2CAKT1GAASMN1; SMN2 | |
| SCHEMBL6199288 | 0.84 | HTR2A (0.45) | HTR2AHTR2CGAASMN1; SMN2 | |
| SCHEMBL6198174 | 0.80 | HTR2A (0.48) | HTR2AHTR2CAKT1SMN1; SMN2 | |
| SCHEMBL6198541 | 0.80 | HTR2A (0.48) | HTR2AHTR2C | |
| SCHEMBL6198264 | 0.80 | HTR2A (0.55) | HTR2AHTR2CAKT1GAA | |
| SCHEMBL6199008 | 0.80 | HTR2A (0.50) | HTR2AHTR2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |