Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199754 | 0.85 | HTR2A (0.48) | HTR2AHTR2C | |
| SCHEMBL6198379 | 0.84 | HTR2A (0.53) | HTR2AHTR2CMAPT | |
| SCHEMBL6201224 | 0.84 | HTR2A (0.48) | HTR2AHTR2CSMN1; SMN2GAA | |
| SCHEMBL2953420 | 0.82 | L3MBTL1 (0.44) | PKMMEN1KMT2ATDP1RAB9A | |
| SCHEMBL6199858 | 0.82 | HTR2A (0.46) | HTR2AMEN1KMT2AHTR2C | |
| SCHEMBL5946836 | 0.79 | HTR2A (0.50) | HTR2APKMMEN1KMT2ATDP1 | |
| SCHEMBL6196599 | 0.77 | HTR2A (0.48) | HTR2AKMT2AHTR2CSMN1; SMN2GAA | |
| SCHEMBL6198174 | 0.77 | HTR2A (0.48) | HTR2AHTR2CSMN1; SMN2LMNAKDM4E | |
| SCHEMBL6199008 | 0.77 | HTR2A (0.50) | HTR2AMEN1KMT2AHTR2CRAB9A | |
| SCHEMBL6198264 | 0.77 | HTR2A (0.55) | HTR2AMEN1KMT2AHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |