Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7234552 | 0.98 | AGXT (0.36) | CHRNA7AGXTACHETDP1IDO1 | |
| SCHEMBL6203275 | 0.79 | IDO1 (0.54) | AGXTIDO1TDO2ESR1ESR2 | |
| SCHEMBL6202004 | 0.78 | IDO1 (0.42) | IDO1TDO2 | |
| SCHEMBL6202821 | 0.78 | IDO1 (0.42) | IDO1TDO2 | |
| SCHEMBL6203172 | 0.78 | IDO1 (0.42) | IDO1TDO2 | |
| Hydrochloric Acid SCHEMBL7227150 | 0.78 | IDO1 (0.55) | AGXTIDO1TDO2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7227164 | 0.77 | IDO1 (0.44) | IDO1TDO2 | |
| Hydrochloric Acid SCHEMBL7227095 | 0.77 | IDO1 (0.44) | IDO1TDO2 | |
| SCHEMBL6203379 | 0.76 | CYP19A1 (0.38) | ALDH1A1 | |
| SCHEMBL27515157 | 0.75 | CHRNA7 (0.32) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |