Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.68 |
| ▸ | HTR2C | P28335 | 6/20 | 0.55 |
| ▸ | CNR1 | P21554 | 8/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201643 | 0.90 | HTR2A (0.79) | HTR2AHTR2CCNR1CNR2 | |
| SCHEMBL6198676 | 0.86 | HTR2A (0.64) | HTR2AHTR2CCNR1CNR2ALDH1A1 | |
| SCHEMBL6199738 | 0.86 | HTR2A (0.64) | HTR2AHTR2CCNR1CNR2ALDH1A1 | |
| SCHEMBL6198211 | 0.85 | HTR2A (0.60) | HTR2AHTR2CCNR1RAF1CNR2 | |
| SCHEMBL6198462 | 0.85 | HTR2A (0.62) | HTR2AHTR2CCNR1CNR2ALDH1A1 | |
| SCHEMBL6196200 | 0.84 | HTR2A (0.65) | HTR2AHTR2CAURKBALDH1A1MAPT | |
| SCHEMBL6199412 | 0.84 | HTR2A (0.56) | HTR2AHTR2CALDH1A1MAPTHPGD | |
| SCHEMBL6195174 | 0.83 | HTR2A (0.60) | HTR2AHTR2CCNR1AURKBALDH1A1 | |
| SCHEMBL15248447 | 0.82 | HTR2A (0.61) | HTR2AHTR2C | |
| SCHEMBL6198156 | 0.81 | TRPV1 (0.62) | HTR2AHTR2CBRAFALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |