SCHEMBL620144

SCHEMBL620144

O=C(c1cc(Cl)cc2nc(N3CCN(C4CC4)CC3)ccc12)C1CC1

nearest known ligand 0.67

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 12/20 0.67
MELK Q14680 4/20 0.39
ALDH1A1 P00352 1/20 0.39
IDE P14735 1/20 0.37
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13648862 0.81 HRH3 (1.00) HRH3
Hydrochloric Acid SCHEMBL3967429 0.80 HRH3 (0.97) HRH3
SCHEMBL13648925 0.74 HRH3 (1.00) HRH3
SCHEMBL13648846 0.74 HRH3 (1.00) HRH3
Hydrochloric Acid SCHEMBL3973108 0.74 HRH3 (0.98) HRH3
Hydrochloric Acid SCHEMBL3971412 0.73 HRH3 (0.97) HRH3
SCHEMBL13648774 0.71 HRH3 (1.00) HRH3
SCHEMBL27892911 0.70 HRH3 (0.71) HRH3
Hydrochloric Acid SCHEMBL3971036 0.70 HRH3 (0.97) HRH3
SCHEMBL13648926 0.68 HRH3 (0.67) HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4370202-B1 XENON GAS FOR USE IN THE TREATMENT OF GLIOMAS UNIV HEIDELBERG (DE) 2026-03-18 EP claimed
US-20260060979-A1 METHOD FOR IMPROVING NEUROPLASTICITY ALTO NEUROSCIENCE INC (US) 2026-03-05 US claimed
US-20250000896-A1 Xenon Gas for Use in the Treatment of Gliomas Universität Heidelberg (DE) 2025-01-02 US claimed
EP-4370202-A1 XENON GAS FOR USE IN THE TREATMENT OF GLIOMAS Universität Heidelberg (DE) 2024-05-22 EP claimed
WO-2023285170-A1 XENON GAS FOR USE IN THE TREATMENT OF GLIOMAS Universität Heidelberg (DE) 2023-01-19 WO claimed
EP-4119191-A1 XENON GAS FOR USE IN THE TREATMENT OF GLIOMAS Universität Heidelberg (DE) 2023-01-18 EP claimed
CN-121902886-B Digital impulse neuron, impulse neural network and realization method thereof 中国科学技术大学 2026-05-22 CN disclosed
CN-122036563-A Synthesis method of aryl F-18 marked sulfonyl chloride and application of aryl F-18 marked sulfonyl chloride in amine compound marking 四川大学 2026-05-15 CN disclosed
EP-4370202-B1 XENON GAS FOR USE IN THE TREATMENT OF GLIOMAS UNIV HEIDELBERG (DE) 2026-03-18 EP disclosed
US-20260060979-A1 METHOD FOR IMPROVING NEUROPLASTICITY ALTO NEUROSCIENCE INC (US) 2026-03-05 US disclosed
US-20250295699-A1 METHODS AND COMPOSITIONS FOR TREATING CORTICAL HYPEREXCITABILITY AND REVERSING STROKE-INDUCED CHANGES IN GENE EXPRESSION AND PROTEIN EXPRESSION SANBIO, INC. (US) 2025-09-25 US disclosed
CN-118615253-B Pirennet microsphere based on multiple emulsion process and preparation method and application thereof 四川大学华西医院 2025-06-03 CN disclosed
CN-119881321-A Application of AMPAR protein group in response to terahertz waves 中国人民解放军军事科学院军事医学研究院 2025-04-25 CN disclosed
US-6015835-A ADMINISTERING TAURINE, HOMOTAURINE, AND/OR METHIONINE MEDDISS, INCORPORATED (JP) 2000-01-18 US disclosed
EP-0797992-A2 Use of taurine, homotaurine and/or methionine for inducing analgesia or anesthesia and treating or preventing ischaemic injury Meddiss, Inc. (JP) 1997-10-01 EP disclosed
US-5364876-A Tranquilizers, analgesics, learning enhancement GUILFORD PHARMACEUTICALS INC. (US) 1994-11-15 US disclosed
EP-0587789-A4 METHODS OF TREATING INJURY TO THE CENTRAL NERVOUS SYSTEM GENSIA INC (US) 1994-09-07 EP disclosed
EP-0587789-A1 METHODS OF TREATING INJURY TO THE CENTRAL NERVOUS SYSTEM GENSIA, INC. (US) 1994-03-23 EP disclosed
US-5236908-A Using adenosine antagonist GENSIA PHARMACEUTICALS, INC. (US) 1993-08-17 US disclosed
WO-1992021337-A1 METHODS OF TREATING INJURY TO THE CENTRAL NERVOUS SYSTEM GENSIA, INC. (US) 1992-12-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260060979-A1 METHOD FOR IMPROVING NEUROPLASTICITY NTRK2, BDNF, GRIN2A HRH3 597/4885MELK 1407/4885ALDH1A1 3173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.